![]() The protective effect was then computed by 1-RR or 1-OR. The relative risk (RR) or odds ratio (OR) of TB provided the measure of vaccine efficacy that we analyzed. At least two readers independently extracted data and evaluated validity. We recorded study design, age range of study population, number of patients enrolled, efficacy of vaccine, and items to assess the potential for bias in study design and diagnosis. Fourteen prospective trials and 12 case-control studies were included in the analysis. Experts from the Centers for Disease Control and Prevention and the World Health Organization, among others, provided lists of all known studies.Ī total of 1264 articles or abstracts were reviewed for details on BCG vaccination, concurrent vaccinated and unvaccinated groups, and TB outcome 70 articles were reviewed in depth for method of vaccine allocation used to create comparable groups, equal surveillance and follow-up for recipient and concurrent control groups, and outcome measures of TB cases and/or deaths. MEDLINE with index terms BCG vaccine, tuberculosis, and human. To quantify the efficacy of BCG vaccine against tuberculosis (TB).
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